枕石漱流

業績一覧

はじめに

業績一覧では私の北海道大学大学院時代ならびに北里大学獣医畜産学部・獣医学部における業績を著書、原著論文ならびに総説に分けて紹介させて頂きます。

著書

  1. 家畜臨床生化学＜第３版＞　第１６章：鉄代謝　　Kaneko JJ　編　久保周一郎，伊沢久夫，戸尾祺明彦　監訳　分担翻訳　近代出版　pp. 717-739.
  2. 獣医生化学実験＜第２版＞　E：秤量法，電子天秤の使い方，Q：電気泳動法，R：デンシトメトリー　　獣医生理学・生理化学教育懇談会　編著　分担執筆　チクサン出版社　pp. 33, 153-171.
  3. 獣医生化学　４章：糖質の構造，７章：糖質の代謝　　斉藤昌之，鈴木嘉彦，横田　博　編　分担執筆　朝倉書店　pp. 38-49, 67-83.

原著論文

  1. Itakura T, Watanabe K, Shiokawa H, Kubo S. 1978. Purification and characterization of acidic adenylate kinase in porcine heart. Eur J Biochem 82(2): 431-437.
  2. Watanabe K, Itakura T, Kubo S. 1979. Distribution of adenylate kinase isoenzymes in porcine tissues and their subcellular localization. J Biochem 85(3): 799-805.
  3. Watanabe K, Kubo S. 1982. Mitochondrial adenylate kinase from chicken liver. Purification, characterization and its cell-free synthesis. Eur J Biochem 123(3): 587-592.
  4. Watanabe K, Yamamoto S, Kubo S. 1984. Biochemical and immunochemical properties of chicken adenylate kinase isoenzymes. Proc Jpn Soc Anim Biochem 16: 1-12.
  5. Watanabe K, Kinoshita T, Kawai N, Tashiro N, Mori T, Kubo S, Yamamoto S. 1985. Adenylate kinase from rat liver. Molecular properties and structural comparison with yeast enzyme. Jpn J Vet Sci 47(1): 63-72.
  6. Watanabe K, Kitagaki T, Yamamoto S. 1987. Immunological cross-reaction between Escherichia coli and mammalian adenylate kinases. Jpn J Vet Sci 49(6): 1180-1182.
  7. Watanabe K, Tanaka K, Kojima H, Imanishi T, Yamamoto S. 1988. Interaction between cytosolic adenylate kinase and nicotinamide adenine dinucleotide. Jpn J Vet Sci 50(2): 509-512.
  8. Watanabe K, Sekine T, Katagi M, Shinbo A, Yamamoto S. 1988. Effect of reduction and carboxamido-methylation on immunogenicity of mitochondrial adenylate kinase (AK2). Jpn J Vet Sci 50(3): 791-796.
  9. Watanabe K, Sohara T, Takeda M, Ueno K, Suzumura N, Rokurouda Y, Rokurouda I, Yamamoto S. 1989. Difference in content ratio of components among horse serum transferrin variants. Jpn J Vet Sci 51(5): 969-974.
  10. Kay MMB, Marchalonis J.J, Hughes J, Watanabe K, Schluter SF. 1990. Definition of a physiologic aging autoantigen by using synthetic peptides of membrane protein band 3: Localization of the active antigenic sites. Proc Natl Acad Sci USA 87(15): 5734-5738.
  11. Orino K, Saji M, Ozaki Y, Ohya T, Yamamoto S, Watanabe K. 1993. Inhibitory effects of horse serum on immunoassay of horse ferritin. J Vet Med Sci 55(1): 45-49.
  12. Orino K, Yamamoto S, Watanabe K. 1993. Fibrinogen as a ferritin-binding protein in horse plasma. J Vet Med Sci 55(5): 785-787.
  13. Watanabe K, Sakashita Y, Orino K, Yamamoto S. 1994. Identification of bovine serum transferrin phenotypes by polyacrylamide gel isoelectric focusing (PAGIEF). J Vet Med Sci 56(2): 421-423.
  14. 瀬戸秀佳，折野宏一，山本晋二，渡辺清隆． 八雲牧場飼育牛におけるトランスフェリン対立遺伝子頻度．北里獣医畜産学会誌 1(2): 94-99.
  15. Watanabe K, Yahikozawa S, Orino K, Yamamoto S. 1995. Immunological cross-reaction between lactoferrin and transferrin. J Vet Med Sci 57(3): 519-521.
  16. 山田真理子，坂田美和子，坪内亜矢子，折野宏一，山本晋二，渡辺清隆． 牛血漿および好中球ラクトフェリン含量．家畜生化学 32(1): 25-30.
  17. Kakuta K, Orino K, Yamamoto S, Watanabe K. 1997. High levels of ferritin and its iron in fetal bovine serum. Comp Biochem Physiol 118A(1):165-169.
  18. Orino K, Eguchi K, Nakayama T, Yamamoto S, Watanabe K. 1997. Sequencing of cDNA clones that encode bovine ferritin H and L chains. Comp Biochem Physiol 118B(3): 667-673.
  19. Watanabe K, Ozawa M, Ochiai H, Kamohara H, Iijima N, Negita H, Orino K, Yamamoto S. 1998. Changes in iron and ferritin in anemic calves infected with Theileria sergenti. J Vet Med Sci 60(8): 943-947.
  20. Watanabe K, Hayashi K, Miyamoto T, Tanaka M, Okano S, Yamamoto S. 2000. Characterization of ferritin and ferritin-binding proteins in canine serum. BioMetals 13(1): 57-63.
  21. 渡辺清隆，折野宏一． 牛胎子における高い鉄貯蔵．日本獣医師会雑誌 53(11): 744-746.
  22. Watanabe K, Muranishi N, Murata Y, Orino K, Okano S, Yamamoto S. 2000. Biochemical properties of canine serum ferritin: iron content and nonbinding to concanavalin A. BioMetals 13(4): 319-324.
  23. Watanabe K, Yamashita Y, Ohgawara H, Sekiguchi M, Satake N, Orino K, Yamamoto S. 2001. Iron content of rat serum ferritin. J Vet Med Sci 63(5): 587-589.
  24. Inagaki M, Kikuchi M, Orino K, Ohnami Y, Watanabe K. 2002. Purification and quantification of lactoferrin in equine seminal plasma. J Vet Med Sci 64(1): 75-77.
  25. Orino K, Kamura S, Natsuhori M, Yamamoto S, Watanabe K. 2002. Two pathways of iron uptake in bovine spleen apoferritin dependent on iron concentration. BioMetals 15(1): 59-63.
  26. Orino K, Higa M, Fujikawa M, Takehara K, Okano S, Yamamoto S, Watanabe K. 2002. Characterization of autoantibodies to ferritin in canine serum. BioMetals 15(2): 161-165.
  27. 荻野心太郎，折野宏一，渡辺清隆． 食餌鉄によるラット体内貯蔵鉄の制御．獣医生化学 39(2): 19-24.
  28. Orino K, Terada A, Yoshida A, Okano S, Higuchi S, Natsuhori M, Watanabe K. 2003. Clearance rates of biotinylated ferritins in canine: A possible physiological role of canine serum ferritin as an iron transporter. BioMetals 16(2): 341-347.
  29. Kikuchi M, Mizoroki S, Kubo T, Ohiwa Y, Kubota M, Yamada N, Orino K, Ohnami Y, Watanabe K. 2003. Seminal plasma lactoferrin but not transferrin reflects gonadal function in dogs. J Vet Med Sci 65(6): 679-684.
  30. Kikuchi M, Takao Y, Tokuda N, Ohnami Y, Orino K, Watanabe K. 2003. Relationship between seminal plasma lactoferrin and gonadal function in horses. J Vet Med Sci 65(11): 1273-1274.
  31. Orino K, Ishiji T, Yamamoto S, Watanabe K. 2004. Characterization of bovine serum ferritin-binding proteins. Comp Biochem Physiol (A) 137(2): 375-381.
  32. Orino K, Harada S, Natsuhori M, Takehara K, Watanabe K. 2004. Kinetic analysis of bovine spleen apoferritin and recombinant H and L chain homopolymers: iron uptake suggests early stage H chain ferroxidase activity and second stage L chain cooperation. BioMetals 17(2): 129-134.
  33. Orino K, Miura T, Muto S, Watanabe K. 2005. Sequence analysis of canine and equine ferritin H and L subunit cDNAs. DNA Sequence 16(1):58-64.
  34. Orino K, Hirata A, Watanabe K. 2005. Sequence analysis of feline ferritin H and L subunit cDNAs. Vet Biochem 42: 7-11.
  35. Orino K, Uehara M, Okano S, Watanabe K. 2006. Purification and characterization of canine serum ferritin-binding proteins. BioMetals 19(3): 315-322.
  36. Orino K, Watanabe S, Ohtsuka H, Kohiruimaki M, Watanabe K. 2006. Measurement of ferritin in bovine milk and its clinical significance. J Dairy Sci 89: 3842-3845.
  37. Abe T, Kinda T, Takano Y, Chikazawa S, Higuchi M, Kawasaki N, Orino K, Watanabe K. 2006. Relationship between body iron stores and diquat toxicity in male Fischer-344 rats. BioMetals 19: 651-657.
  38. Kolm G, Klein D, Knapp E, Watanabe K, Walter I. 2006. Lactoferrin expression in the horse endometrium: Relevance in persisting mating-induced endometritis. Vet Immunol Immunopathol 114: 159-167.
  39. Barton MH, Hurley D, Norton N, Heusner G, Costa L, Jones S, Byars D, Watanabe K. 2006. Serum lactoferrin and immunoglobulin G concentrations in healthy or ill neonatal foals and healthy adult horses. J Vet Intern Med 20: 1457-1462.
  40. Orino K, Hamada S, Hashimoto M, Nambo Y, Kondo T, Watanabe K. 2006. Identification of horse anti-ferritin autoantibody. J Equine Sci 17: 113-119.
  41. Higuchi M, Kobayashi S, Kawasaki N, Hamaoka K, Watabiki S, Orino K, Watanabe K. 2007. Protective effects of wheat bran against diquat toxicity in male Fischer-344 rats. Biosci Biotechnol Biochem 71(7): 1621-1625.
  42. Seki T, Kunichika T, Watanabe K, Orino K. 2008. Apolipoprotein B binds ferritin by hemin-mediated binding: evidence of direct binding of apolipoprotein B and ferritin to hemin. BioMetals 21(1): 61-69.
  43. Takaesu A, Watanabe K, Takai S, Sasaki Y, Orino K. 2008. Sequence analysis of dolphin ferritin H and L subunits and possible iron-dependent translational control of dolphin ferritin gene. Acta Vet Scand 50: 42.
  44. Sugawara G, Inoue R, Watanabe K, Ohtsuka H, Orino K. 2009. Bovine α-casein is a ferritin-binding protein and inhibitory factor of milk ferritin immunoassay. J Dairy Sci 92(8): 3810-3814.
  45. Sakamoto H, Kuboi T, Nagakura T, Hayashi S, Hoshi F, Mutoh K, Watanabe K, Orino K. 2009. Characterization of feline serum ferritin-binding proteins: the presence of a novel ferritin-binding protein as an inhibitory factor in feline ferritin immunoassay. Biometals 22(5): 793-802.
  46. Naoi T, Shibuya N, Inoue H, Mita S, Kobayashi S, Watanabe K, Orino K. 2010. The effect of tert-butylhydroquinone-induced oxidative stress in MDBK cells using XTT assay: Implication of tert-butylhydroquinone-induced NADPH generating enzymes. J Vet Med Sci 72(3): 321-326.
  47. 渡辺清隆，田中梨恵，秋末真吾，吉川泰永，折野宏一． 鉄欠乏性貧血ラットにおける三二酸化鉄の吸収性の評価．新薬と臨床 59(7): 1127-1132.
  48. 近澤征史郎，小林秀樹，堀泰智，星史雄，金井一亨，伊藤直之，佐藤淳，山本祥大，立花麻子，春原瑠美，打出毅、折野宏一，渡辺清隆，樋口誠一． 犬の多中心型リンパ腫における血清フェリチン濃度の変動．動物臨床医学 19(3): 71-77.
  49. Higuchi M, Oshida J, Orino K, Watanabe K. 2011. Wheat bran protects Fischer-344 rats from diquat-induced oxidative stress by activating antioxidant system: selenium as an antioxidant. Biosci Biotechnol Biochem 75(3): 496-499.
  50. Hashimoto M, Nambo Y, Kondo T, Watanabe K, Orino K. 2011. A study on the presence of ferritin-binding proteins in fetal horse plasma. J Equine Sci 22(1): 1-7.
  51. Nakai M, Murata N, Yoda T, Yoshikawa Y, Watanabe K, Orino K. 2011. Binding of mammalian and avian ferritins with biotinylated hemin: demonstration of preferential binding of the H subunit to heme. J Vet Med Sci 73(3): 313-318.
  52. Watanabe M, Yuge M, Uda A, Yoshikawa Y, Watanabe K, Orino K. 2011. Structural and functional analyses of chicken liver ferritin. Poultry Sci 90: 1489-1495.
  53. Higuchi M, Yoshikawa Y, Orino K, Watanabe K. 2011. Effect of diquat-induced oxidative stress on iron metabolism in male Fischer-344 rats. Biometals 24(6): 1123-1131.
  54. Usami A, Tanaka M, Yoshikawa Y, Watanabe K, Ohtsuka H, Orino K. 2011. Heme-mediated binding of α-casein to ferritin: evidence for preferential α-casein binding to ferrous iron. Biometals 24(6): 1217-1224.
  55. Ohya T, Kondo T, Yoshikawa Y, Watanabe K, Orino K. 2011. Change of ferritin-binding activity in the serum of foal after birth. J Equine Sci 22(4): 73-76.
  56. Yoshikawa Y, Morimatsu M, Ochiai K, Okuda K, Taoda T, Chikazawa S, Shimamura A, Omi T, Bonkobara M, Orino K, Watanabe K. 2012. Establishment of a PCR analysis method for canine BRCA2. BMC Research Notes 5: 173.
  57. Shibuya N, Kobayashi S, Yoshikawa Y, Watanabe K, Orino K. 2012. Effects of oxidative stress caused by tert-butylhydroquinone on cytotoxicity in MDCK cells. J Vet Med Sci 74(5): 583-589.
  58. Shibuya N, Yoshikawa Y, Watanabe K, Ohtsuka H, Orino K. 2012. Iron-dependent binding of bovine milk α-casein with holo-lactoferrin, but not holo-transferrin. Biometals 25(5): 1083-1088.
  59. Yoshikawa Y, Ochiai K, Morimatsu M, Suzuki Y, Wada S, Taoda T, Iwai S, Chikazawa S, Orino K, Watanabe K. 2012. Effects of the missense mutations in canine BRCA2 on BRC repeat 3 functions and comparative analyses between canine and human BRC repeat 3. PLOS ONE 7: e45833.
  60. Chikazawa S, Hori Y, Hoshi F, Kanai K, Ito N, Sato J, Orino K, Watanabe K, Higuchi S. 2013. Development of a sandwich enzyme-linked immunosorbent assay to detect and measure serum levels of canine ferritin. J Vet Med Sci 75(4): 515-517.
  61. Kanno Y, Ohtsuka H, Yoshikawa Y, Watanabe K, Orino K. 2013. Measurement of ferritin and anti-ferritin autoantibodies in serum and colostrum of Holstein and Japanese Black cows. Anim Sci J 84(7): 556-561.
  62. Mieno A, Yamamoto Y, Yoshikawa Y, Watanabe K, Mukai T, Orino K. 2013. Binding analysis of ferritin with heme using α-casein and biotinylated-hemin: detection of heme-binding capacity of Dpr derived from heme synthesis-deficient Streptococcus mutans. J Vet Med Sci 75(8): 1101-1105.
  63. Takahashi K, Kondo T, Yoshikawa Y, Watanabe K, Orino K. 2013. The presence of heat-labile factors interfering with binding analysis of fibrinogen with ferritin in horse plasma.  Acta Vet Scand 55: 70.
  64. Chikazawa S, Nakazawa T, Hori Y, Hoshi F, Kanai K, Ito N, Orino K, Watanabe K, Higuchi S. 2013. Change in serum ferritin concentration in experimentally induced anemia of chronic inflammation in dogs. J Vet Med Sci 75(11): 1419-1426.
  65. Chikazawa S, Hori Y, Kanai K, Ito N, Hoshi F, Orino K, Watanabe K, Higuchi S. 2013. Factors influencing measurement of serum iron concentration in dogs: diurnal variation and hyperferritinemia. J Vet Med Sci 75(12): 1615-1618.
  66. Numata M, Kondo T, Nambo Y, Yoshikawa Y, Watanabe K, Orino K. 2013. Change of antibody levels to ferritin in the sera of foals after birth: possible transfer of maternal anti-ferritin autoantibody via colostrum and age-related anti-ferritin autoantibody production. Anim Sci J 84(12): 782-789.
  67. Higashi S, Nagasawa K, Yoshikawa Y, Watanabe K, Orino K. 2014. Characterization analysis of human anti-ferritin autoantibodies. Antibodies 3: 169-181.
  68. Schnell SA, Ohtsuka H, Kakinuma S, Yoshikawa Y, Watanabe K, Orino K. 2015. Iron and ferritin levels in the serum and milk of bovine leukemia virus-infected dairy cows. Front Vet Sci 2(12)
  69. Yoshikawa Y, Morimatsu M, Ochiai K, Ishiguro-Oonuma T, Wada S, Orino K, Watanabe K. 2015. Reduced canine BRCA2 expression levels in mammary gland tumors. BMC Vet Res 11(159)
  70. Okada A, Yoshikawa Y, Watanabe K, Orino K. 2015. Analysis of the binding of bovine and human fibrinogen to ferritin: evidence that fibrinogen is a common ferritin-binding protein in mammals. Biometals 28(4): 679-685.

総説

  1. 折野宏一，渡辺清隆，山本晋二． フェリチンの分子性状および生理学的意義．獣医生化学 37(1): 1-10.
  2. Orino K, Watanabe K. 2007. Anti-ferritin autoantibody as mammalian common ferritin-binding protein. Vet Biochem 44: 1-8.
  3. Orino K, Watanabe K. 2008. Molecular, physiological and clinical aspects of the iron storage protein ferritin. Vet J 178(2): 191-201.

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